Nick Chiappini in Elk: "Really friggin excellent work from L..."

Really friggin excellent work from Liam Ball's group on bringing meta-arylation of phenols to the realm of possibility for Bi(V)

Ball consistently wows me with the scale of some of his group's preps (16 g of the divergent bismacycle!!)

https://www.nature.com/articles/s41557-022-01101-0

Nature

meta-Selective C–H arylation of phenols via regiodiversion of electrophilic aromatic substitution - Nature Chemistry

The strong regiochemical preferences of electrophilic aromatic substitution have played a key role in defining the diversity of accessible chemical space. Now, it has been shown that the electrophilic arylation of phenols can be achieved at the electronically disfavoured meta-position via a formal 1,2-migration of a key σ-complex intermediate.

December 12, 2022 at 6:25:04 PM

And also for the stoichiometric skeptics out there, recovery of the bismacycle is really straightforward. Basically run your column and then flush with polar solvent and a bit of acetic acid and you get the bismacycle back intact (from their previous work with these)